Tips for printing
ACEI - Angiotensin Fetopathy

IBIS: International Birth Defects Information Systems - Home Page

About I.B.I.S.
Home
Search Topics
Search all contents
Standards

"In the News"
Messages...
Questions/comments
Report Dead Links
Disclaimer
 S.O.S. - Exchange
Join I.B.I.S.
Genetics Birth Defects Center
Ukrainian-American Birth Defects Program
Pandora's Word Box
Medical Etymology
MedWord
Birth Defects
Gallery - Music
Books - Old Maps - Etchings
 
Notice!
The theme of this page is beyond the scope of the mission of I.B.I.S. The links shown below are highly selected and of limited scope.

Special Resources
SOS: Ask experts or consultants for information
ACEI - Angiotensin Fetopathy


A Selection of Internet Sites

[*] Outstanding
[P] For Professionals



Under Development


Surveillance for Angiotensin - Converting Enzyme Inhibitor Use During the First Trimester of Pregnancy -- United States, Canada, and Israel
March 21, 1997 / 46(11);240-242 ... Angiotensin-converting enzyme inhibitors (ACEIs) are effective antihypertensive drugs, but use of ACEIs during the second and third trimesters of pregnancy has been associated with a pattern of defects known as ACEI fetopathy. The predominant feature of the fetopathy is renal tubular dysplasia. Other associated conditions include hypocalvaria, intrauterine growth retardation (IUGR), and patent ducts arteriosus (PDA). These features may be related to fetal hypotension secondary to ACEI-induced decreases in fetal angiotensin or increased dradykinin (1,2) … Of 79 women enrolled, 66 (84%) had ACEI exposure limited to the first trimester of pregnancy (less than or equal to 14 weeks' gestation, as measured since the time of their last menstrual periods). These women had 48 live births from 1987 through 1995 (Table_1). The rate of spontaneous abortion among these women was 23%. Among the 48 live births, three cases of IUGR were documented. One infant with IUGR was from twins delivered at 36 weeks' gestation; the other two were full-term. Another child had a PDA that required surgical ligation at age 18 months. That infant was born at 40 weeks' gestation to a woman who discontinued therapy with an ACEI at 71/2 weeks' gestation. She also was treated with digoxin … There were no children with renal tubular dysplasia who had been exposed to ACEIs exclusively during the first trimester …

[**][P] ACEI During Pregnancy
New Mexico Medicaid (July 2, 1997) ... Fetal and neonatal injury have been reported in over 50 women receiving ACEIs during pregnancy ... Result of ACEI exposure during the first trimester only ... Exposure during the 2nd and 3rd trimester may result in adverse fetal and neonatal outcomes in 10-20% of the cases ...

              Search this site
 
  powered by FreeFind  
IBIS:International Birth Defects Information Systems

This site offers information mostly for educational purposes. This site is not intended to alter health care protocols nor to serve  as a sole source of  medical information.  Please read full disclaimer. Always seek the advice of your local health care provider.

Copyright 1998 - 2002 I.B.I.S. All rights reserved.
Sponsor: I.B.I.S. | Site Concept: W. W., D. C. | Page Content: W. Wertelecki, M. D.
Email: Webmaster


21/January/2002 dc